Answer: Half life is significantly longer in non-smokers
Olanzapine has an interesting characteristic i.e. its half life gets significantly prolonged in nonsmoker patients, maybe up to more than 50 hours! Also, half life stays prolonged with kidney and liver insufficiency.
Another less well known effect of Olanzapine is its tendency to cause hyperglycemia.
#pharmacology
Reference:
Skrobik YK, Bergeron N, Dumont M, Gottfried SB. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med 2004; 30:444.
Olanzapine has an interesting characteristic i.e. its half life gets significantly prolonged in nonsmoker patients, maybe up to more than 50 hours! Also, half life stays prolonged with kidney and liver insufficiency.
Another less well known effect of Olanzapine is its tendency to cause hyperglycemia.
#pharmacology
Reference:
Skrobik YK, Bergeron N, Dumont M, Gottfried SB. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med 2004; 30:444.
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