cytoabsorb

Q: Which of the following major inflammatory molecule does not get removed via hemadsorption? 

A) interleukin-6 
B) interleukin-10


Answer: B

Hemadsorption is actually hemoperfusion through sorbent-containing cartridges, a process alike continuous renal replacement therapy (CRRT). Hemadsorption provides a larger surface area to enhance the removal of cytokines and inflammatory molecules involved during cytokine storm. This leads to its applicability and popularity in COVID-19 treatment. The most widely available commercial sorbent is CytoSorb which has porous polymer beads. The data is still experimental. Unfortunately, though this process theoretically sounds effective it does not remove two major inflammatory molecules, endotoxin and interleukin-10.

#COVID-19
#sepsis
#infectious-diseases



References:

1. Honore PM, Jacobs R, Joannes-Boyau O, et al. Newly designed CRRT membranes for sepsis and SIRS--a pragmatic approach for bedside intensivists summarizing the more recent advances: a systematic structured review. ASAIO J 2013; 59:99. 

 2. Quintel M. CytoSorb™ whole blood cytokine adsorption–results of a controlled randomized trial. Presented at the 32nd International Symposium on Intensive Care and Emergency Medicine. March 20–23, 2012 

 3. Schadler, D., Brederlau J., Jorres, A., Marx, G., Meier-Hellmann, A., Putensen, C., Quintel, M., Spies, C., Porzelius, C., Engel, C., Weiler, N., Kuhlmann, M. Extracorporeal cytokine hemoadsorption in patients with severe sepsis and acute lung injury. Am J Respr Crit Care Med , 2013, pp.A5241