PCF

Q: What is platelet contractile force (PCF)?


Answer: 

Platelet contractile force (PCF) is an interesting parameter to measure global platelet function. During platelet activation, contractile forces within the cytoskeleton of platelets mediate both changes of shape and pseudopod formation. PCF is a direct measurement of these forces. Despite normal platelet count, platelet function may be decreased in uremia, Glanzmann thrombasthenia, cardiopulmonary bypass, and GPIIb/IIIa inhibitors. 

#hematology


References: 

1. Carr ME Jr, Zekert SL. Measurement of platelet-mediated force development during plasma clot formation. Am J Med Sci 1991; 302:13. 

2.  Carr ME Jr. Measurement of platelet force: the Hemodyne hemostasis analyzer. Clin Lab Manage Rev 1995; 9:312. 

3.  Greilich PE, Carr ME Jr, Carr SL, Chang AS. Reductions in platelet force development by cardiopulmonary bypass are associated with hemorrhage. Anesth Analg 1995; 80:459. 

4. Carr ME Jr, Carr SL, Hantgan RR, Braaten J. Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus. Thromb Haemost 1995; 73:499. 

5. Greilich PE, Carr ME, Zekert SL, Dent RM. Quantitative assessment of platelet function and clot structure in patients with severe coronary artery disease. Am J Med Sci 1994; 307:15.