PTP

Q: What is Posttransfusion purpura (PTP)?

Answer: Post-transfusion purpura (PTP) is an adverse reaction to blood transfusion that occurs when the body produces alloantibodies to introduced platelets' antigens. Posttransfusion purpura typically occurs 5-12 days following a transfusion. This syndrome can be induced by platelet transfusion, a small amount of platelets contaminating red blood cell transfusion, or, occasionally, following fresh frozen plasma (FFP) transfusion. PTP is most common in women with multiple pregnancies and in men who have undergone previous transfusions.

Thrombocytopenia responds to intravenous immunoglobulin (IVIG) and Plasmapheresis.

#hematology

Reference:

1. Hawkins J, Aster RH, Curtis BR. Post-Transfusion Purpura: Current Perspectives. J Blood Med. 2019 Dec 9;10:405-415. doi: 10.2147/JBM.S189176. PMID: 31849555; PMCID: PMC6910090.