Monday, October 3, 2011

Q: Half life of Cisatracurium (Nimbex) is prolong in?

A) Hepatic failure
B) Renal failure
C) Geriatric patients
D) Hypothermia
E) Both C and D

Answer: E (Both C and D)

Half life of Nimbex is approximately 22 to 29 minutes, following administration of a single intravenous dose. The half-life is not substantially affected by the duration of administration (approximately 26 ± 11 minutes in ICU patients receiving cisatracurium via intravenous infusion), type of anesthesia, or hepatic or renal function impairment, but is slightly longer in geriatric patients than in younger adults. In individuals undergoing induced hypothermia (body temperature of 25 to 28 °C), the half-life is prolonged as compared with the half-life during normothermia.

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