Q: 22 years old male is brought to ER with acute symptoms of ataxia, nausea, vomiting, severe sedation, and dizziness. Primidone is recently added to patient's anti-seizure medicines. Primidone is a prodrug of? (select one)
In the body, Primidone gets converted into two active metabolites, named phenobarbital and phenylethylmalonamide (PEMA). Phenobarbital binds to the GABA(A) receptor. PEMA enhances the activity of phenobarbital.
Although primidone is a prodrug of phenobarbital and as expected many side-effects are the same as of phenobarbital, primidone can produce acute adverse reactions independent of it consisting of dizziness, ataxia, nausea, and vomiting.
References:1. Abou-Khalil BW. Antiepileptic Drugs. Continuum (Minneap Minn) 2016; 22:132.