Sunday, April 12, 2020

Neutropenic fever

Q: What is the official definition of neutropenic fever?

Answer: Per Infectious Diseases Society of America (IDSA) fever in neutropenic patients is defined as a single oral temperature of ≥38.3°C (101°F) or a temperature of ≥38.0°C (100.4°F) sustained over a one-hour period.

The objective of the above question is to enhance the learning that even in the normal individuals' range of normal body temperature can have a wide range with an upper limit of 38°C (100.8°F). The range can be anywhere from 35.6°C (96.0°F) to 38.2°C (100.8°F).



1. Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of America. Clin Infect Dis 2011; 52:e56.

2. Mackowiak PA, Wasserman SS, Levine MM. A critical appraisal of 98.6 degrees F, the upper limit of the normal body temperature, and other legacies of Carl Reinhold August Wunderlich. JAMA 1992; 268:1578.

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