Q: How statins can have some indirect benefit in COVID-19 patients?
Answer: Statins can have a beneficial effect in COVID-19 patients via two mechanisms
First, a large proportion of COVID-19 hospitalized patients have underlying cardiac history and statins may cont to play a beneficial role.
Second, data from previous epidemics of SARS-CoV and MERS-CoV shows the dysregulation of MYD88 pathway and association with poor outcome. Statins stabilizes and inhibits MYD88 levels. Similar could be true for COVID-19. Stabalization of MYD88 pathway may help in decrease inflammation during cytokine release storm of COVID-19.
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References:
Yuan S. Statins May Decrease the Fatality Rate of Middle East Respiratory Syndrome Infection. mBio 2015; 6:e01120.
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