Sunday, April 22, 2012

Q: Which one is more effective - IV Chloramphenicol or PO Chloramphenicol?

Answer: PO Chloramphenicol

Interestingly and unlike most other drugs PO Chloramphenicol is more effective than IV preparation of Chloramphenicol.

Pure chloramphenicol does not dissolve in water so it has to be prepare with succinate ester. Chloramphenicol succinate ester is an inactive prodrug and must first be hydrolysed to chloramphenicol; however, during hydrolysis 30% of the drug is lost.

To be effective, the dose needs to be increased to be equivalent to the oral dose!

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