Sunday, May 20, 2012

A note on False positive Troponin I due to RF

Troponin complex is located on the thin filament of skeletal and myocardial muscle. The high sensitivity and specificity of cardiac troponin to detect myocardial injury is well documented. However, various factors can interfere with the TnI assay, leading to falsely elevated levels. This include particularly rheumatoid factor (RF).

Rheumatoid factor causes interference in the immunoassays. 5% of healthy people may have circulating rheumatoid factor, and approximately 1% of patients with elevated cardiac TnI levels may have this elevation solely because of the rheumatoid factor.


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