Sunday, December 22, 2013

Q: 32 year old female is admitted to ICU after cardio-pumonary collapse secondary to Hanta Virus infection. What is the treatment of Hanta Virus Cardio-Pumonary syndrome (HCPS)?

Answer: Supportive - Probable ECMO insertion

Though ribavirin has been suggested in HCPS but has not shown any survival benefit. Research literature is available on use of neutralizing antibodies (passive immunotherapy) for HCPS but so far has not been used much in clinical practice.

Supportive treatment till symptoms resolved.


Mertz GJ, Miedzinski L, Goade D, et al. Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America. Clin Infect Dis. Nov 1 2004;39(9):1307-13.

Bharadwaj M, Nofchissey R, Goade D, Koster F, Hjelle B. Humoral immune responses in the hantavirus cardiopulmonary syndrome. J Infect Dis. Jul 2000;182(1):43-8.

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