Q: In Hemolytic Anemia, does haptoglobin increase or decrease? (Choose one) 



Answer: Decrease 

Haptoglobin is the protein that in blood plasma, haptoglobin binds free hemoglobin released from erythrocytes with high affinity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system, mostly in the spleen. 

In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels.