Q: What are the less well know risk factors for C.Diff. Colitis in ICU beside previous antibiotics usage, age and severity of illness?

Answer:

1. Antacid therapy
2. Stool softeners
3. Nasogastric or oro-gastric tubes
4. Enteral feeds
5. Cathartics

References:

1. Poutanen SM, Simor AE: Clostridium difficile–associated diarrhea in adults. CMAJ 2004;171:51-58

2. Thielman NM, Wilson KH: Antibiotic-associated colitis -  Mandell GL, Bennett JE, Dolin R (eds): Principles and Practice of Infectious Diseases, 6th ed, vol 1. Philadelphia: Elsevier, 2005, pp 1249-1262.