Q: What is the advantage Fosinopril (Monopril) over other ACE-Inhibitors?

Answer:  Unlike other ACE inhibitors which are primarily excreted by the kidneys, fosinopril is eliminated from the body via both renal and hepatic routes. This makes fosinopril little more a drug of safer choice than other ACE inhibitors for heart failure patients with some kidney function impairment. Fosinopril is de-esterified by the liver or by gastrointestinal mucosa and is converted to its active form, fosinoprilat.