Q: What is the dose of Methylene blue (MB) in Vasoplegic Syndrome?

Answer: A single dose of IV MB, 2 mg/kg over 20-min infusion. Continuous MB infusion could be an option for patients not responding to a single dose of MB.

Reference:

Leyh RG, Kofidis T, Strüber M, Fischer S, Knobloch K, Wachsmann B, Hagl C,Simon AR, Haverich A. Methylene blue: the drug of choice for catecholamine-refractory vasoplegia after cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003;125:1426-1431