Monday, February 3, 2014

Q: What is the most important clinical relevance of TTKG (The trans-tubular potassium gradient)?

Answer: TTKG is calculated by following formula

TTKG = urine K+ X serum osmolality/serum K+ X urine osmolality

  • A TTKG of greater than 8 indicates that aldosterone is present and that the collecting duct is responsive to it.
  • A TTKG of less than 5 in the presence of hyperkalemia indicates aldosterone deficiency or resistance.

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