Tuesday, July 22, 2014

Q: What are the therapeutic target level of Digoxin in Congestive heart failure (CHF) and non-CHF patients?


CHF patients = 0.5–0.9 mcg/L ,
Non CHF patients like for atrial fibrillation rate control, its 0.5–2 mcg/L


Adams KF Jr., Gheorghiade M, Uretsky BF, et al. Clinical benefits of low serum digoxin concentrations in heart failure. J Am Coll Cardiol. 2002;39:946–953.

Ahmed A, Rich MW, Love TE, et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial. Eur Heart J. 2006;27:178–186.

Rathore SS, Curtis JP, Wang Y, et al. Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA. 2003;289:871–878.

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