Sunday, October 12, 2014

Q: 52 year old male with ESRD is admitted to ICU with septic shock. Patient is started on CRRT. Patient has previous history of A.fib. Pt. went into RVR (Rapid ventricular rate). Cardiology service started IV amiodarone. Is Amiodarone dialyzable?

Answer: No

Amiodarone is eliminated primarily by hepatic metabolism and biliary excretion. Desethylamiodarone (DEA) is the major active metabolite of amiodarone. Neither amiodarone nor DEA is dialyzable.

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