Thursday, December 11, 2014

Q: Tumor Lysis Syndrome can do all of the following except:

A) Hyperkalemia

B) Hyperphosphatemia

C) Hypercalcemia

D) Hyperuricemia

Answer: C

Tumor Lysis syndrome causes hypocalcemia instead of hypercalcemia

Cairo and Bishop defined a classification system for tumor lysis syndrome dividing it into categories

Laboratory tumor lysis syndrome: 
(abnormality in 2 or more of the following, occurring within three days before or seven days after chemotherapy).
  • uric acid > 8 mg/dL or 25% increase
  • potassium > 6 meq/L or 25% increase
  • phosphate > 4.5 mg/dL or 25% increase
  • calcium < 7 mg/dL or 25% decrease

Clinical tumor lysis syndrome: 
(laboratory tumor lysis syndrome plus one or more of the following)
  • increased serum creatinine (1.5 times upper limit of normal)
  • cardiac arrhythmia or sudden death
  • seizure


Cairo MS, Bishop M (October 2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br. J. Haematol. 127 (1): 3–11.

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