Tuesday, December 9, 2014

Q: What is considered as an endpoint success in Barbiturate coma therapy (BCT)  from ICP (intra cranial pressure) control perspective in neurotrauma patients?

Answer: ICP < 20 mmHg for at least 48 hours, at a minimum

Patients, whose ICPs are successfully controlled by pentobarbital, had at least five times greater chance of survival. 


Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. High dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg. 1988;69:15–23.

Etienne D, Jacques B, Arlette V, Florence L, Jean LV. Barbiturate coma for intracranial hypertension: clinical observations. J Crit Care. 2002;17:58–62.

Horsley JS. The intracranial pressure during barbital narcosis. Lancet. 1937;1:141–143.

Michael WL, Scott AD, Mary ES, Roger RB, Dan RT. The efficacy of barbiturate coma in the management of uncontrolled intracranial hypertension following neurosurgical trauma. J Neurotrauma. 1994;11:325–331.

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