Thursday, January 29, 2015

Q: How Cisatracurium degradation is related to body temperature?

Answer: Cisatracurium is degraded by Hofmann elimination and ester hydrolysis in plasma. Hofmann elimination is a temperature- and plasma pH-dependent process. An increase in body pH and temperature favors the elimination process.

Trivia: Cisatracurium was marketed as Nimbex. "Nimbex" was derived from inserting an "i" to word "Nmbex," which stood for excellent Neuromuscular blocker.

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