Q: After how many hours of Propofol infusion, hypertriglyceridemia may become an issue?
Risk of hypertriglyceridemia ( > or = 400 mg/dl) and pancreatitis in ICU are
- median infusion rate of propofol around 50 microg/kg/minute
- median time around 54 hours (higher with longer duration of propofol infusion)
- Older age
- longer ICU stay
- Admission in medical ICU
Devlin JW, Lau AK, Tanios MA. - Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors.- .Pharmacotherapy. 2005 Oct;25(10):1348-52