Tuesday, April 14, 2015

Q: After how many hours of Propofol infusion, hypertriglyceridemia may become an issue?

Answer: About 48 hours

Risk of hypertriglyceridemia ( > or = 400 mg/dl) and pancreatitis in ICU are
  • median infusion rate of propofol around 50 microg/kg/minute
  • median time around 54 hours (higher with longer duration of propofol infusion)
  • Older age
  • longer ICU stay
  • Admission in medical ICU


Devlin JW, Lau AK, Tanios MA. - Propofol-associated hypertriglyceridemia and pancreatitis in the intensive care unit: an analysis of frequency and risk factors.- .Pharmacotherapy. 2005 Oct;25(10):1348-52

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