Q: Simultaneous use of which commonly used drugs
during intubation may exacerbate etomidate-related adrenal
insufficiency?
Answer: Opioids and
benzodiazepines.
Simultaneous use of etomidate with opioids and/or
benzodiazepines has shown tendency to exacerbate etomidate-related adrenal
insufficiency, at least in 2 studies.
References:
1. Daniell, Harry (2008). "Opioid and benzodiazepine
contributions to etomidate-associated adrenal insufficiency". Intensive Care
Medicine 34 (11): 2117–8.
2. Daniell, HW (2008). "Opioid contribution to decreased cortisol levels in critical care patients". Arch Surg 143 (12): 1147–1148.
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