Monday, May 11, 2015

Q: Which drugs beside glucocorticoids may increase the risk of Propofol infusion syndrome (PRIS) in ICU ?

Answer: Catecholamines

Many triggering and predisposing factors for PRIS have been identified, but to all of them the priming factor is critical illness, particularly neurologic injury, trauma, sepsis or pancreatitis - beside age, cumulative dose of propofol, infusion of catecholamines, corticosteroids and interestingly inadequate delivery of carbohydrates.


Vasile B, Rasulo F Candiani A, et al. The pathophysiology of  propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med 2003;29:1417-25.

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