Wednesday, November 18, 2015

Q: Cisatracurium is the most commonly used neuromuscular blockade in ICU. Which one common pitfall should be kept in mind while using this drug? 

Answer: Patients with profound sepsis may require higher dose as they may not only have a delayed response but also reduced response to described standard dosing regimens in textbooks.


Liu X, Kruger PS, Weiss M, Roberts MS. The pharmacokinetics and pharmacodynamics of cisatracurium in critically ill patients with severe sepsis. Br J Clin Pharmacol 2012; 73:741.

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