Q: What is the difference between dose of Naloxone given intra-nasally and via other routes?


Answer:  Naloxone can be administered via intravenous, intramuscular, subcutaneous or intranasal routes. Dose for all routes except for intranasal is 0.4 mg of the 0.4 mg/1 mL concentration. For intranasal route higher dose is required up to 2 mg of the 1 mg/1 mL concentration. Intranasal administration is recommended with a mucosal atomizer device to ensure proper spray on nasal mucosa.