Friday, December 11, 2015

Q: What is the difference between dose of Naloxone given intra-nasally and via other routes?

Answer:  Naloxone can be administered via intravenous, intramuscular, subcutaneous or intranasal routes. Dose for all routes except for intranasal is 0.4 mg of the 0.4 mg/1 mL concentration. For intranasal route higher dose is required up to 2 mg of the 1 mg/1 mL concentration. Intranasal administration is recommended with a mucosal atomizer device to ensure proper spray on nasal mucosa.

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