Wednesday, March 16, 2016

Q: What is the role of Indomethacin in acute liver failure?

Answer:  It has been reported that increased Intra-Cranial Pressure (ICP) in fulminant  hepatic failure which stays refractory to all treatments may respond to a single intravenous dose of 25 mg  Indomethacin given over one minute. Proposed mechanism of action is cerebral vasoconstriction.


 1. Clemmesen JO, Hansen BA, Larsen FS. Indomethacin normalizes intracranial pressure in acute liver failure: a twenty-three-year-old woman treated with indomethacin. Hepatology 1997; 26:1423.

2. Tofteng F, Larsen FS. The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 2004; 24:798.

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