Thursday, August 18, 2016

Q: Does "edge-to-edge leaflet repair device" (trade name=MitraClip) implantation for Transcatheter mitral valve repair (TMVR) requires infective endocarditis prophylaxis?

Answer:  There is a lack of consensus among experts regarding antibiotic prophylaxis for infective endocarditis for patients undergoing minimally invasive "edge-to-edge leaflet repair device"  implantation for Transcatheter mitral valve repair (TMVR). European Society of Cardiology infective endocarditis guidelines (2015) suggest antibiotic prophylaxis, but American Heart Association/American College of Cardiology valve guidelines (2014) does not require infective endocarditis prophylaxis. Patients should be instructed to practice dental hygiene and watch for any sign of infection.


1. Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015; 36:3075.

2. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014; 63:e57.

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