Q: Does "edge-to-edge leaflet repair device" (trade name=MitraClip) implantation for Transcatheter mitral valve repair (TMVR) requires infective endocarditis prophylaxis?


Answer:  There is a lack of consensus among experts regarding antibiotic prophylaxis for infective endocarditis for patients undergoing minimally invasive "edge-to-edge leaflet repair device"  implantation for Transcatheter mitral valve repair (TMVR). European Society of Cardiology infective endocarditis guidelines (2015) suggest antibiotic prophylaxis, but American Heart Association/American College of Cardiology valve guidelines (2014) does not require infective endocarditis prophylaxis. Patients should be instructed to practice dental hygiene and watch for any sign of infection.


References: 

1. Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015; 36:3075.

2. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014; 63:e57.