Sunday, October 9, 2016

Q: 47-year-old male is admitted to ICU with hypertensive crisis. On examination, patient appears to be of tall stature. ENT exam showed a rounded surgical scar on the neck (which he attributed to his previous thyroid tumor) and protruded tongue exam is shown below. your diagnosis?

Answer: MEN 2B

Multiple endocrine neoplasia (MEN) are combinations of various tumors of endocrine glands. They are autosomal dominant. It is not possible to describe them in detail here but in nutshell they are grouped as

MEN I - Pituitary adenoma, Parathyroid hyperplasia and Pancreatic tumors 
MEN 2a - Medullary Thyroid Cancer, Parathyroid hyperplasia and Pheochromocytoma 
MEN 2b - Medullary Thyroid Cancer, Marfanoid habitus, mucosal neuromas and Pheochromocytoma

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