Thursday, October 27, 2016

Q: Folic acid is recommended as an adjuvant therapy in Ethylene Glycol or Methanol poisoning if a patient receives Famipzol as a treatment. What is the dose?


In the situation like above,  the dose of  folic acid is 50 mg IV every six hours till clinical and laboratory parameters normalize. Folinic acid can be used in place of folic acid with similar dosing. The objective of above question is to point the way higher dose of folic acid in toxic alcohol poisonings treatment, than in other clinical situations. 

The evidence is weak but it is a common practice to add thiamine and pyridoxine along with folic acid.


 Barceloux DG, Bond GR, Krenzelok EP, et al. American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol 2002; 40:415.

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