Tuesday, November 8, 2016

Q: Which infectious cause is prone to give acquired protein C deficiency?

Answer:  Meningococcemia causing purpura fulminans 

Other (mostly non-infectious) causes of acquired protein C deficiency are
  • Acute thrombosis
  • Warfarin therapy 
  • Liver disease 
  • Vitamin K deficiency 
  • DIC


Lorenzo Alberio, Bernhard Lämmle, and Charles T. Esmon - Protein C Replacement in Severe Meningococcemia: Rationale and Clinical Experience - Clin Infect Dis. (2001) 32 (9): 1338-1346.

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