Answer: Meningococcemia causing purpura fulminans
Other (mostly non-infectious) causes of acquired protein C deficiency are
- Acute thrombosis
- Warfarin therapy
- Liver disease
- Vitamin K deficiency
Lorenzo Alberio, Bernhard Lämmle, and Charles T. Esmon - Protein C Replacement in Severe Meningococcemia: Rationale and Clinical Experience - Clin Infect Dis. (2001) 32 (9): 1338-1346.