Q: Why purpura fulminans requires treatment with protein C concentrate instead of FFP though it contains Protein C?
Answer: Half life of Protein C in FFP is very short, so it should not be used as a source of protein C.
Smith OP, White B, Vaughan D, et al. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet 1997; 350:1590.
Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325:1565.