Thursday, November 24, 2016

Q: Why purpura fulminans requires treatment with protein C concentrate instead of FFP though it contains Protein C?

Answer:  Half life of Protein C in FFP is very short, so it should not be used as a source of protein C. 


 Smith OP, White B, Vaughan D, et al. Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet 1997; 350:1590. 

Dreyfus M, Magny JF, Bridey F, et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325:1565.

No comments:

Post a Comment