Q: What are the six requisite of pathophysiology of cholesterol emboli?

Answer:

1. Presence of a plaque in a proximal, large-caliber artery (such as the internal carotid artery, the iliac arteries, or the aorta) 
2. Plaque rupture (spontaneous, traumatic, or iatrogenic) 
3.  Embolization of plaque debris (containing cholesterol crystals, platelets, fibrin, and calcified detritus) 
4.  Lodging of the emboli in small to medium arteries with a diameter of 100 to 200 μm, leading to mechanical occlusion 
5.  Foreign-body inflammatory response to cholesterol emboli 
6.  End-organ damage due to a combined effect of mechanical plugging and inflammation

Reference: 

Itzhak Kronzon, Muhamed Saric - Cholesterol Embolization Syndrome, Circulation. 2010;122:631-641 Originally published August 9, 2010