Pearls on Intensive Care Medicine Practice - Project "Critical Care A Day"
Saturday, March 18, 2017
.Q: At what level of creatinine, renal adjustment of apixaban (Eliquis) should be considered?
Answer: Serum creatinine more than or equal to 1.5 mg/dL
Three main category advised for dose reduction of apixaban are
age at 80 years or above
body weight at 60 kg or less
Serum creatinine 1.5 mg/dL or more
When two or more of the above present simultaneously, it became more compelling to reduce the dose. Pharmacy should be consulted for dose management to avoid undue bleeding as apixaban has no reversal available yet (still under development with name of Andexanet alfa).