Saturday, March 18, 2017

.Q: At what level of creatinine, renal adjustment of apixaban (Eliquis) should be considered?

Answer: Serum creatinine more than or equal to 1.5 mg/dL

Three main category advised for dose reduction of apixaban are
  • age  at 80 years or above
  • body weight at 60 kg or less
  • Serum creatinine 1.5 mg/dL or more
When two or more of the above present simultaneously, it became more compelling to reduce the dose. Pharmacy should be consulted for dose management to avoid undue bleeding as apixaban has no reversal available yet (still under development with name of Andexanet alfa).

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