Wednesday, September 27, 2017

Q: What is "Ketofol"?

Answer: "Ketofol" is a nickname of combination used for Ketamine and Propofol. There is a very weak evidence out there that this combination may work better for procedures. Ketamine is a dissociative anesthetic and provides sedation, analgesia, and amnesia, and exerts a sympathomimetic effect. Propofol is an ultra short-acting hypnotic agent, with an added advantage of antiemetic property.

Recommend mix is 1:1 ratio.


1.  Shah A, Mosdossy G, McLeod S, Lehnhardt K, Peddle M, Rieder M. A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children. Ann Emerg Med. 2011;57(5):425-33.e2. 

3. Andolfatto G, Abu-Laban R, Zed P, et al. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med. 2012;59(6):504-12.e1-2.

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