Q; Why 4 coagulation factors combination is called FEIBA?
Answer: FEIBA stands for 'factor eight inhibitor bypassing agent'. It is a combination of Factors II, VII, IX and X.
FEIBA is used in patients who have antibodies or deficiency of Factor VIII e.g. in haemophilic patients. FEIBA contains the proenzymes of the prothrombin complex factors, prothrombin, FVII, FIX and FX, but only very small amounts of their activation products, with the exception of FVIIa, which is contained in FEIBA in greater amounts. FEIBA controls bleeding by induction and facilitation of thrombin generation, (a process for which FV is crucial).
Turecek PL, Váradi K, Gritsch H, Schwarz HP - FEIBA: mode of action - Haemophilia. 2004 Sep;10 Suppl 2:3-9.