Q: 24 year old male is admitted in ICU. Oncology service made decision to start bleomycin for his underlying cancer. Which organ insufficiency may increase the risk of bleomycin induced pulmonary fibrosis?
A) previous lung insufficiency
B) renal insufficiency
C) liver insufficiency
E) pancreatic insufficiency
Total cumulative dose is mainly responsible for its lung toxicity and as most of the bleomycin is eliminated via kidney, renal insufficiency increases the risk of pulmonary fibrosis. Another risk factor is rapid infusion of the drug.
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