Colistin and CRRT

Q: Which one drug need adjustment on Continuous Renal Replacement Therapy (CRRT), because it get adsorption to the membrane?


Answer: Colistin

Many drugs get adsorption to CRRT membrane but does not require adjustment of dose solely for adsorption. Colistin is the only drug which requires adjustment of dose as 40 to 60 percent of it get adsorption to membrane, and very little get recovered in the effluent.


Reference:

Markou N, Fousteri M, Markantonis SL, et al. Colistin pharmacokinetics in intensive care unit patients on continuous venovenous haemodiafiltration: an observational study. J Antimicrob Chemother 2012; 67:2459.