DIC and Organs

Q: Out of the following major organs, which organ is more prone to insult in acute disseminated intravascular coagulation (DIC)

A) Renal 
B) Liver 
C) Lung
D) Central nervous system (CNS)
E) Adrenal


Answer: A 

Vascular micro-thrombosis, hemorrhage, leading to tissue hypoxia is a well known mechanism for organ dysfunctions in acute DIC. Kidney is the most vulnerable organ in acute DIC. In ICU, it requires high vigilance as need for CRRT may arise very quickly.



Reference:

Siegal T, Seligsohn U, Aghai E, Modan M. Clinical and laboratory aspects of disseminated intravascular coagulation (DIC): a study of 118 cases. Thromb Haemost 1978; 39:122.