Wednesday, April 11, 2018

Half life of Protamine

Q: The half life of protamine is?

A) 5 minutes
B) 15 minutes
C) 30 minutes
D) 60 minutes
E) It correlates with heparin level in the plasma

Answer: A

Protamine is a known reversal of heparin. It has a very short  half-life of about five minutes. This information is clinically significant as recurrent anticoagulation may occur after initial reversal of heparin, and may require re-dosing of protamine. 


Butterworth J, Lin YA, Prielipp RC, Bennett J, Hammon JW, James RL. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. .Ann Thorac Surg. 2002 Nov;74(5):1589-95.

No comments:

Post a Comment