Q: The half life of protamine is?
A) 5 minutes
B) 15 minutes
C) 30 minutes
D) 60 minutes
E) It correlates with heparin level in the plasma
Answer: A
Protamine is a known reversal of heparin. It has a very short half-life of about five minutes. This information is clinically significant as recurrent anticoagulation may occur after initial reversal of heparin, and may require re-dosing of protamine.
Reference:
Butterworth J, Lin YA, Prielipp RC, Bennett J, Hammon JW, James RL. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. .Ann Thorac Surg. 2002 Nov;74(5):1589-95.
No comments:
Post a Comment