Q: What is the 'rule of thumb' to infuse one unit of Fresh Frozen Plasma (FFP)?
In patients with no documented cardiac dysfunction, one unit of FFP can be given over 1.5 hours. And, if there is a concern for volume overload, it should be given slowly over four hours.
To put exactly in terms of calculated value: healthy patients should be transfused with 2 to 3 mL/kg/hour, and cardiac failure patients with 1 mL/kg/hour.
Chowdary P, Saayman AG, Paulus U, et al. Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 2004; 125:69.