Tuesday, October 9, 2018

Intravenous Lipid Emulsion therapy and laboratory measurements

Q: 54-year-old male is admitted to ICU with calcium channel blocker overdose. A decision has been made to start Intravenous Lipid Emulsion (ILE therapy) due to the failure of conventional antidotes and hemodynamic instability. All of the following laboratory measurement may get effected except?

A) serum magnesium 
B) serum creatinine 
C) serum lipase
D) serum potassium 
E) all of the above

Answer: D

As expected ILE therapy interferes with most laboratory measurements of electrolytes and drug levels. Interestingly, it does not affect two important lab measurements frequently used in ICU, potassium, and troponin-I. 




Grunbaum AM, Gilfix BM, Gosselin S, Blank DW. Analytical interferences resulting from intravenous lipid emulsion. Clin Toxicol (Phila) 2012; 50:812.

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