Q: Docusate is a commonly used anti-diarrheal agent used in ICU. It is? (select one)
A) A surfactant
B) An Osmotic agent
C) a stimulant laxatives
D) a nerve ending stimulator
E) a bulk-forming laxative
Answer: A
Docusate sodium is a stool softener in a layman term but medically it is a surfactant. Its mechanism of action is little more complex and interesting. It is an anionic surfactant, means a surface-active agent. It lowers the surface tension at the oil-water interface of the feces, allowing more water and lipids to enter the stool. High water and lipid content of the stool facilitates natural defecation.
Although it is a very benign medicine, it may cause contact dermatitis as a side effect.
#gastroenterology
#pharmacology
References:
1. PDR - https://www.pdr.net/drug-summary/Colace-Capsules-docusate-sodium-1023
2. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005; 100:936.
A) A surfactant
B) An Osmotic agent
C) a stimulant laxatives
D) a nerve ending stimulator
E) a bulk-forming laxative
Answer: A
Docusate sodium is a stool softener in a layman term but medically it is a surfactant. Its mechanism of action is little more complex and interesting. It is an anionic surfactant, means a surface-active agent. It lowers the surface tension at the oil-water interface of the feces, allowing more water and lipids to enter the stool. High water and lipid content of the stool facilitates natural defecation.
Although it is a very benign medicine, it may cause contact dermatitis as a side effect.
#gastroenterology
#pharmacology
References:
1. PDR - https://www.pdr.net/drug-summary/Colace-Capsules-docusate-sodium-1023
2. Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol 2005; 100:936.
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