Q: What leads to a clogged ventilator circuit filter in an intubated patient due to the administration of continuous INHALED epoprostenol?
Answer: The use of inhaled epoprostenol is still considered off-label. Inhaled epoprostenol is commonly being reconstituted with glycine, which is a very viscous diluent, and may clogged the ventilator circuit. Constant vigilance is required and ventilator circuit should be changed frequently i.e, around every 4 hours. Increase resistance in ventilatory circuit may cause elevated peak airway pressures.
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