Risk factors - pyogenic liver abscesses

Q: Which group of drugs are considered risk factors in the development of pyogenic liver abscesses? 


Answer: Proton-pump inhibitors (PPIs)

Some of the major risk factors in the development of pyogenic liver abscesses are diabetes mellitus, underlying hepatobiliary disease, underlying pancreatic disease, history of liver transplant, and regular use of proton-pump inhibitors.

#hepatology
#pharmacology
#infectiousdiseases


References:

1.  Lin HF, Liao KF, Chang CM, et al. Correlation between proton pump inhibitors and risk of pyogenic liver abscess. Eur J Clin Pharmacol 2017; 73:1019.

2. Kaplan GG, Gregson DB, Laupland KB. Population-based study of the epidemiology of and the risk factors for pyogenic liver abscess. Clin Gastroenterol Hepatol 2004; 2:1032. 

3. Thomsen RW, Jepsen P, Sørensen HT. Diabetes mellitus and pyogenic liver abscess: risk and prognosis. Clin Infect Dis 2007; 44:1194.