Q: Intravenous (IV) administration of haloperidol may have a higher risk of extrapyramidal side effects than oral administration? (select one)
Although IV Haloperidol has a high-grade warning from FDA, it is very commonly used at the bedside. Interestingly, IV Haloperidol tends to cause lower extrapyramidal side effects than oral administration.
Not fully explained but this is probably due to avoidance of first-pass metabolism, saving brain from the effects of metabolites.
Menza MA, Murray GB, Holmes VF, Rafuls WA: Decreased extrapyramidal symptoms with intravenous haloperidol. J Clin Psychiatry 1987; 48:278–280