Q: In life-threatening liver dysfunction due to yellow fever, which liver enzyme tends to have a higher value?
A) alanine aminotransferase (ALT)
B) aspartate aminotransferase (AST)
In contrast to other viral hepatitides, serum aspartate aminotransferase (AST) levels may exceed those of alanine aminotransferase (ALT) by 2 to 3 times. And the severity of enzymes elevation is proportional to the disease severity.
Tuboi SH, Costa ZG, da Costa Vasconcelos PF, Hatch D. Clinical and epidemiological characteristics of yellow fever in Brazil: analysis of reported cases 1998-2002.
Trans R Soc Trop Med Hyg 2007; 101:169. Oudart JL, Rey M. Proteinuria, proteinaemia, and serum transaminase activity in 23 confirmed cases of yellow fever]. Bull World Health Organ 1970; 42:95.