Sunday, February 10, 2019

Quinolones route of metabolism

Q: Which of the Quinolones does not require adjustment in renal failure?

A) moxifloxacin 

B) levofloxacin 
C) ciprofloxacin 
 D) norfloxacin 
E) delafloxacin

Answer: A

Moxifloxacin, levofloxacin and ciprofloxacin are the most commonly used quinolones in ICU. 

Despite the institution of hemodialysis or continuous renal replacement therapy (CRRT) - ciprofloxacin and levofloxacin need dose adjustment. 

 Moxifloxacin does not require any adjustment in renal failure as major route of metabolism for this quinolone is hepatic.



Stass H, Kubitza D. Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man. J Antimicrob Chemother 1999; 43 Suppl B:83.

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