Quinolones route of metabolism

Q: Which of the Quinolones does not require adjustment in renal failure?

A) moxifloxacin 
B) levofloxacin 
C) ciprofloxacin 
 D) norfloxacin 
E) delafloxacin


Answer: A

Moxifloxacin, levofloxacin and ciprofloxacin are the most commonly used quinolones in ICU. 

Despite the institution of hemodialysis or continuous renal replacement therapy (CRRT) - ciprofloxacin and levofloxacin need dose adjustment. 

 Moxifloxacin does not require any adjustment in renal failure as major route of metabolism for this quinolone is hepatic.


#pharmacology


Reference:

Stass H, Kubitza D. Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man. J Antimicrob Chemother 1999; 43 Suppl B:83.