Q: Thymectomy should be performed even in non-thymomatous myasthenia gravis (MG)? ( select one)
A) True
B) False
Answer: A
The famous multi-center MGTX trial, published in 2016 has pretty much resolved the above controversy. 126 patients were randomized between extended transsternal thymectomy plus alternate-day prednisone, and alternate-day prednisone alone.
The former group did better over three years with the time-weighted average Quantitative Myasthenia Gravis score. Also, the average requirement for alternate-day prednisone and hospitalization for MG exacerbations was lower thymectomy group over three years.
#surgical-critical-care
References:
Wolfe GI, Kaminski HJ, Aban IB, et al. Randomized Trial of Thymectomy in Myasthenia Gravis. N Engl J Med 2016; 375:511.
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