Wednesday, September 11, 2019


Q: 32 year old female is admitted to ICU with lupus associated pulmonary embolism. Rheumatology service diagnosed her lupus secondary to her prescription of hydralazine. Various 'panels' of lab tests have been send. In Hydralazine-associated-lupus, Anti-double stranded (ds) DNA antibodies is supposed to be? (select one)

A) Negative
B) Positive

Answer: A

Although Anti-ds-DNA are usually positive in drug-induced disease with other agents, they are typically absent in drug-induced lupus due to procainamide, hydralazine, and isoniazid.



Iyer P, Dirweesh A, Zijoo R. Hydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody. Case Rep Rheumatol. 2017;2017:5245904. doi:10.1155/2017/5245904

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